Research record
Overview
Compound name: 5-Amino-1MQ
Alternative name: 5-Amino-1-methylquinolinium (commonly shortened as 1MQ / 5-Amino-1MQ)
Compound classification: Small-molecule NNMT inhibitor (not a peptide)
Brief factual description:
5-Amino-1MQ is a synthetic small molecule developed as a potent inhibitor of nicotinamide N-methyltransferase (NNMT). It is researched for its role in regulating cellular energy metabolism, adipose tissue function, and fat accumulation through modulation of NAD⁺ and methylation pathways.
Mechanism of Action
Primary biological target: Nicotinamide N-methyltransferase (NNMT)
Affected systems: Metabolic, adipose, NAD⁺ signaling
Core mechanisms:
Direct inhibition of NNMT enzymatic activity
Preservation of intracellular NAD⁺
Reduced methyl donor depletion (SAM conservation)
Downstream effects:
Increased cellular energy expenditure
Reduced lipid accumulation in adipocytes
Enhanced mitochondrial metabolic signaling
