Research record
Overview
Compound name: Cagrilintide
Development code: AM833
Compound classification: Synthetic peptide; long-acting amylin receptor agonist
Brief factual description:
Cagrilintide is a long-acting synthetic analog of the hormone amylin, designed to activate amylin receptors involved in appetite regulation, gastric emptying, and energy balance. It is being investigated primarily for obesity and metabolic disorders, including in combination with GLP-1 receptor agonists.
Mechanism of Action
Primary biological targets: Amylin receptors (calcitonin receptor complexes with RAMP proteins)
Affected systems: Central nervous system, gastrointestinal, metabolic
Receptor selectivity:
High affinity for amylin receptor subtypes (AMY1, AMY2, AMY3)
Downstream signaling effects:
Appetite suppression via brainstem and hypothalamic pathways
Delayed gastric emptying
Reduced caloric intake and meal size
