Research record
Overview
Compound name: CJC-1295
Alternative names: DAC:GHRH (for the long-acting form)
Compound classification: Synthetic peptide; growth hormone–releasing hormone (GHRH) analog
Brief factual description:
CJC-1295 is a synthetic peptide analog of growth hormone–releasing hormone designed to stimulate endogenous growth hormone secretion by acting on the pituitary gland. It is studied in both short-acting (no DAC) and long-acting (DAC-modified) forms.
Mechanism of Action
Primary biological targets: Growth hormone–releasing hormone receptors (GHRH-R) on pituitary somatotroph cells
Affected systems: Endocrine (growth hormone and IGF-1 axis)
Receptor selectivity: High specificity for GHRH receptors
Downstream signaling effects:
Stimulation of growth hormone synthesis and pulsatile secretion
Secondary increase in circulating IGF-1 levels




