Research record
Overview
Compound name: Dermorphin
Compound classification: Endogenous amphibian opioid peptide
Brief factual description:
Dermorphin is a naturally occurring heptapeptide originally isolated from the skin secretions of certain South American frogs (Phyllomedusa species). It is notable for its exceptionally high potency and selectivity as a μ-opioid receptor agonist, exceeding that of morphine on a molar basis.
Mechanism of Action
Primary biological targets: μ-Opioid receptor (MOR)
Affected systems: Central nervous system, pain pathways
Receptor selectivity:
Very high selectivity and affinity for μ-opioid receptors
Downstream signaling effects:
Inhibition of adenylate cyclase
Reduced neuronal excitability
Decreased neurotransmitter release in pain pathways
