Research record
Overview
Compound name: KPV
Full sequence: Lys–Pro–Val
Compound classification: Synthetic tripeptide; alpha-MSH–derived fragment
Brief factual description:
KPV is a three–amino acid peptide derived from alpha-melanocyte-stimulating hormone (α-MSH). It retains anti-inflammatory activity without melanocortin receptor–mediated pigmentation effects and has been studied primarily for intestinal inflammation, immune modulation, and epithelial barrier protection.
Mechanism of Action
Primary biological targets: Intracellular inflammatory signaling pathways
Affected systems: Immune, gastrointestinal
Core mechanisms
Inhibition of NF-κB activation
Suppression of pro-inflammatory cytokine production
Downstream effects
Reduced TNF-α, IL-6, and IL-1β signaling
Preservation of epithelial tight junction integrity
Modulation of macrophage inflammatory responses
Importantly, KPV operates independently of melanocortin receptors, distinguishing it from full α-MSH.
