Research record
Overview
Compound name: Melanotan I
Alternative names: Afamelanotide; NDP-α-MSH
Compound classification: Synthetic peptide; α-melanocyte-stimulating hormone (α-MSH) analog
Brief factual description:
Melanotan I, also known as Afamelanotide, is a synthetic analog of α-melanocyte-stimulating hormone designed to selectively stimulate melanin production in the skin. Unlike Melanotan II, it exhibits minimal activity at melanocortin receptors associated with sexual arousal and appetite.
Mechanism of Action
Primary biological targets: Melanocortin-1 receptor (MC1R)
Affected systems: Integumentary (skin), melanocyte signaling
Receptor selectivity:
High selectivity for MC1R
Downstream signaling effects:
Activation of adenylate cyclase
Increased intracellular cAMP
Upregulation of melanin synthesis in melanocytes
