Research record
Overview
Compound name: SS-31
Alternative name: Elamipretide
Development code: Bendavia; MTP-131
Compound classification: Synthetic mitochondria-targeted tetrapeptide
Brief factual description:
SS-31 (Elamipretide) is a small synthetic peptide designed to selectively localize to the inner mitochondrial membrane, where it binds cardiolipin and stabilizes mitochondrial structure. It is being investigated for its ability to improve mitochondrial bioenergetics, reduce reactive oxygen species, and restore cellular energy production in diseases associated with mitochondrial dysfunction.
Mechanism of Action
Primary biological targets: Cardiolipin in the inner mitochondrial membrane
Affected systems: Mitochondrial, metabolic, muscular, cardiovascular
Receptor selectivity:
Not receptor-mediated; accumulates directly in mitochondria
Downstream signaling effects:
Stabilization of mitochondrial cristae
Improved electron transport chain efficiency
Reduced cytochrome c peroxidase activity
Decreased reactive oxygen species production
Enhanced ATP generation
